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1. (WO2017156124) HYPERPOLARIZED MICRO-NMR SYSTEM AND METHODS

Pub. No.:    WO/2017/156124    International Application No.:    PCT/US2017/021355
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: G01R 33/30
G01R 33/465
G01N 24/08
G01R 33/28
G01R 33/36
Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: KESHARI, Kayvan R.
JEONG, Sangmoo
Title: HYPERPOLARIZED MICRO-NMR SYSTEM AND METHODS
Abstract:
Described herein are micro-coil hyperpolarized NMR systems and methods for measuring metabolic flux in living and non-living samples. Such systems can perform high throughput measurements (with multiple coils) of metabolic flux without destroying the material, making it useful to analyze tumor biopsies, cancer stem cells, and the like. In certain embodiments, a hyperpolarized micromagnetic resonance spectrometer (HMRS), described herein, is used to achieve real-time, significantly more sensitive (e.g., 103-fold more sensitive) metabolic analyses of live cells or non-living samples. In this platform, a suspension mixed with hyperpolarized metabolites is loaded into a miniaturized detection coil (e.g., about 2 μL), where the flux analysis can be completed within a minute without significant changes in viability. The sensitive and rapid analytical capability of the provided systems enables rapid assessment of metabolic changes by a given drug, which may direct therapeutic choices in patients.