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1. (WO2017156078) DELIVERY OF NITRIC OXIDE-RELEASING PHOSPHOLIPIDS, LIPOSOMES, AND HIGH DENSITY LIPOPROTEIN-LIKE NANOPARTICLES (HDL NPS) BY DRUG ELUTING STENTS AND INTRA-ARTERIAL INJECTION

Pub. No.:    WO/2017/156078    International Application No.:    PCT/US2017/021293
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: A61L 31/16
A61L 31/04
A61K 9/51
A61K 47/24
A61K 33/00
Applicants: NORTHWESTERN UNIVERSITY
NANYANG TECHNOLOGICAL UNIVERSITY
Inventors: THAXTON, C., Shad
RINK, Jonathan
VENKATRAMAN, Subbu
Title: DELIVERY OF NITRIC OXIDE-RELEASING PHOSPHOLIPIDS, LIPOSOMES, AND HIGH DENSITY LIPOPROTEIN-LIKE NANOPARTICLES (HDL NPS) BY DRUG ELUTING STENTS AND INTRA-ARTERIAL INJECTION
Abstract:
Nanostructures having a lipid layer which are useful for delivering nitric oxide are provided herein. Methods of treating disease using the nanostructures are also provided, including methods of treating vascular diseases, angiogenesis, ischemia- reperfusion, etc. Implantable devices coated with the nanostructures are also encompassed within the invention.