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1. (WO2017156074) CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF

Pub. No.:    WO/2017/156074    International Application No.:    PCT/US2017/021288
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: C07D 245/02
C07D 273/08
A61K 38/12
A61P 29/00
A61P 35/00
A61P 43/00
Applicants: BLADE THERAPEUTICS, INC.
Inventors: BUCKMAN, Brad Owen
NICHOLAS, John Beamond
YUAN, Shendong
Title: CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
Abstract:
The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.