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1. (WO2017156058) GITR ANTIBODIES, METHODS, AND USES

Pub. No.:    WO/2017/156058    International Application No.:    PCT/US2017/021258
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: A61K 39/395
C07K 16/28
Applicants: JANSSEN BIOTECH, INC.
Inventors: HOLLAND, Cam
KEHOE, John
SNYDER, Linda
SEPULVEDA, Alejandro
VILLAREAL, Daniel
Title: GITR ANTIBODIES, METHODS, AND USES
Abstract:
Provided herein are antibodies that specifically bind to GITR. Also described are related polynucleotides capable of encoding the provided GITR-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to enhance an immune response in a subject against cancer.