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1. (WO2017156034) METHODS OF EVALUATING A CELLULAR SAMPLE FOR HER-2/NEU EXPRESSION AND COMPOSITIONS FOR PRACTICING THE SAME

Pub. No.:    WO/2017/156034    International Application No.:    PCT/US2017/021205
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: A61K 39/395
G01N 15/14
G01N 33/50
G01N 33/53
G01N 33/574
C12Q 1/00
Applicants: BECTON, DICKINSON AND COMPANY
Inventors: SNOWDEN, Eileen
BLAESIUS, Rainer
HAHN, Friedrich
PORTER, Warren
FERGUSON, Mitchell
Title: METHODS OF EVALUATING A CELLULAR SAMPLE FOR HER-2/NEU EXPRESSION AND COMPOSITIONS FOR PRACTICING THE SAME
Abstract:
Methods of evaluating a cellular sample for HER-2/neu expression are provided. Aspects of the methods include flow cytometrically obtaining fluorescence emission data from a cellular sample fluorescently labelled HER-2/neu specific binding member and employing the sample fluorescence emission data with standard fluorescence emission data to obtain a value of fluorescently labelled HER-2/neu specific binding members bound per cell. Compositions, devices and kits for performing these methods are also provided