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1. (WO2017156015) MICRORNAS AND METHODS OF THEIR USE

Pub. No.:    WO/2017/156015    International Application No.:    PCT/US2017/021178
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: C12N 15/113
A61K 31/7088
A61P 35/00
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
MIRECULE, INC.
Inventors: SALEH, Anthony, D.
VAN WAES, Carter
CHEN, Zhong
CHENG, Hui
Title: MICRORNAS AND METHODS OF THEIR USE
Abstract:
Disclosed herein are methods of treating a tumor in a subject, including administering to the subject one or more miRNA nucleic acids or variants (such as mimics or mimetics) thereof with altered expression in the tumor. Also disclosed herein are compositions including one or more miRNA nucleic acids. In some examples, the miRNA nucleic acids are modified miRNAs, for example, and miRNA nucleic acid including one or more modified nucleotides and/or a 5'-end and/or 3'-end modification. In particular examples, the modified miRNA nucleic acid is an miR-30a nucleic acid. Further disclosed herein are methods of diagnosing a subject as having a tumor with altered expression of one or more miRNA nucleic acids. In some embodiments, the methods include detecting expression of one or more miRNAs in a sample from the subject and comparing the expression in the sample from the subject to a control.