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1. (WO2017155981) PROTEIN-CHAPERONED T-CELL VACCINES

Pub. No.:    WO/2017/155981    International Application No.:    PCT/US2017/021136
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: A61K 39/00
A61K 39/39
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors: IRVINE, Darrell
WITTRUP, Karl, Dane
MEHTA, Naveen, K.
RAKHRA, Kavya
ZHU, Eric, Franklin
Title: PROTEIN-CHAPERONED T-CELL VACCINES
Abstract:
Protein antigens are provided. The protein antigens typically include a peptide antigen conjugated or fused to a chaperone protein to form a "chaperone-antigen" that increases lymph node uptake; improves an immune response; or a combination thereof relative to the peptide antigen alone. The immune response can be, for example, increased antigen-specific proliferation, enhanced cytokine production, stimulation of differentiation and/or effector functions, promotion of survival, rescue from exhaustion and/or anergy of T cells, or a combination thereof. Chaperon-antigens can also be used to induce tolerance and increase immune suppressive responses. In the most preferred embodiments, the peptide antigen is fused to the chaperone protein to form a fusion protein. The "chaperone-antigen" can be combined with an adjuvant to form a vaccine and administered to a subject to modulate an immune response to the antigen. Methods of increasing immune responses, treating cancer and infectious diseases and inducing tolerance are also provided.