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1. (WO2017155973) AAV-MEDIATED EXPRESSION USING A SYNTHETIC PROMOTER AND ENHANCER
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Pub. No.: WO/2017/155973 International Application No.: PCT/US2017/021124
Publication Date: 14.09.2017 International Filing Date: 07.03.2017
IPC:
C12N 15/86 (2006.01) ,A61K 48/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
UNIVERSITY OF IOWA RESEARCH FOUNDATION [US/US]; 112 N Capitol Street 6 Gilmore Hall Iowa City, Iowa 52242, US
Inventors:
ENGELHARDT, John F.; US
YAN, Ziying; US
Agent:
PERDOK, Monique, M.; US
BEEKMAN, Marvin L., Reg. No. 38,377; US
ARORA, Suneel, Reg. No. 42,267; US
BLACK, David W., Reg. No. 42,331; US
SCHEER, Bradley W., Reg. No. 47,059; US
GOULD, James R., Reg. No. 72,086; US
WOO, Justin N., Reg. No. 62,686; US
BIANCHI, Timothy E., Reg. No. 39,610; US
MCCRACKIN, Ann M., Reg. No. 42,858; US
Priority Data:
62/304,65607.03.2016US
Title (EN) AAV-MEDIATED EXPRESSION USING A SYNTHETIC PROMOTER AND ENHANCER
(FR) EXPRESSION MÉDIÉE PAR AAV UTILISANT UN PROMOTEUR ET UN ACTIVATEUR SYNTHÉTIQUES
Abstract:
(EN) An isolated recombinant parvovirus vector comprising a synthetic enhancer comprising plurality of enhancer sequences operably linked to a promoter, and methods of using the vector, are provided.
(FR) L'invention concerne un vecteur de parvovirus de recombinaison isolé comprenant un activateur synthétique comprenant plusieurs séquences activatrices liées de manière fonctionnelle à un promoteur, et des méthodes d'utilisation du vecteur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)