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1. (WO2017155942) SUBSTITUTED HETEROCYCLES AS C-MYC TARGETING AGENTS

Pub. No.:    WO/2017/155942    International Application No.:    PCT/US2017/021082
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: C07D 231/18
C07D 231/12
C07D 231/14
C07D 231/16
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/04
C07D 405/04
C07D 498/04
A61K 31/415
A61K 31/4155
A61K 31/4439
A61K 31/496
A61K 31/497
A61K 31/5377
A61P 35/00
Applicants: NORTHWESTERN UNIVERSITY
Inventors: SCHILTZ, Gary E.
MISHRA, Rama K.
HAN, Huiying
ABDULKADIR, Sarki A.
IZQUIERDO-FERRER, Javier
JAIN, Atut D.
Title: SUBSTITUTED HETEROCYCLES AS C-MYC TARGETING AGENTS
Abstract:
Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.