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1. (WO2017155937) STABILIZED RADIOLABELED ANTI-CD45 IMMUNOGLOBULIN COMPOSITIONS
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Pub. No.: WO/2017/155937 International Application No.: PCT/US2017/021076
Publication Date: 14.09.2017 International Filing Date: 07.03.2017
Chapter 2 Demand Filed: 31.08.2017
IPC:
A61K 47/68 (2017.01) ,A61K 39/395 (2006.01) ,A61K 101/02 (2006.01) ,A61K 51/10 (2006.01) ,C07K 16/28 (2006.01)
[IPC code unknown for A61K 47/68][IPC code unknown for A61K 39/395][IPC code unknown for A61K 101/02][IPC code unknown for A61K 51/10][IPC code unknown for C07K 16/28]
Applicants:
ACTINIUM PHARMACEUTICALS, INC. [US/US]; 275 Madison Avenue, 7th Floor New York, NY 10016, US
Inventors:
DAVE, Kaushik, J.; US
SHARMA, Shubh, D.; US
Agent:
DUKES, Michael, E.; US
CHEUNG, Noland, J.; US
GEARY, Lisa, E.; US
TOLHURST, Frederick, L.; US
Priority Data:
62/304,53707.03.2016US
Title (EN) STABILIZED RADIOLABELED ANTI-CD45 IMMUNOGLOBULIN COMPOSITIONS
(FR) COMPOSITIONS D'IMMUNOGLOBULINES ANTI-CD45 RADIO-MARQUÉES STABILISÉES
Abstract:
(EN) Compositions and methods are described for stabilizing a radio-iodinated monoclonal IgG antibody for up to 17 days against radiolytic decomposition. The stabilized radiolabeled murine antibody binding the CD45 antigen expressed on various forms of lymphomas is useful as a radio-therapeutic and diagnostic agent in the treatment of human malignancies of hematopoietic origin, including lymphomas.
(FR) L'invention concerne des compositions et des méthodes permettant de stabiliser un anticorps IgG monoclonal radio-marqué à l'iode pendant jusqu'à 17 jours contre une décomposition par radiolyse. L'anticorps murin radio-marqué stabilisé, se liant à l'antigène CD45 exprimé sur diverses formes de lymphomes, est utile en tant qu'agent radio-thérapeutique et de diagnostic dans le traitement de tumeurs malignes humaines d'origine hématopoïétique, notamment des lymphomes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)