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1. (WO2017155935) PHARMACEUTICAL AGENTS TARGETING CANCER STEM CELLS
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Pub. No.: WO/2017/155935 International Application No.: PCT/US2017/021073
Publication Date: 14.09.2017 International Filing Date: 07.03.2017
IPC:
A61K 31/635 (2006.01) ,A61K 31/409 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for A61K 31/635][IPC code unknown for A61K 31/409][IPC code unknown for A61P 35]
Applicants:
THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, Maryland 21218, US
Inventors:
HOQUE, Mohammad O.; US
SIDRANSKY, David; US
OKI, Akira; US
Agent:
FEULNER, Gregory; US
Priority Data:
62/304,63207.03.2016US
Title (EN) PHARMACEUTICAL AGENTS TARGETING CANCER STEM CELLS
(FR) AGENTS PHARMACEUTIQUES CIBLANT DES CELLULES SOUCHES CANCÉREUSES
Abstract:
(EN) Methods for preventing or treating subjects having cancer based on the identification of pharmaceutical agents that target cancer stem cells (CSCs) have been identified. These methods include administering to the subject an effective amount of a COX2 inhibitor and an effective amount of a YAP1 inhibitor. In addition, methods of enhancing chemotherapeutic responses in cancer patients have been discovered and are described herein.
(FR) L'invention concerne l'identification de méthodes de prévention ou de traitement de sujets atteints d'un cancer sur la base de l'identification d'agents pharmaceutiques qui ciblent des cellules souches cancéreuses (cSC). Les méthodes consistent à administrer au sujet une quantité efficace d'un inhibiteur de COX2 et une quantité efficace d'un inhibiteur YAP1. De plus, des méthodes d'amélioration de réponses chimiothérapeutiques chez des patients atteints d'un cancer ont été découvertes et sont ici décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)