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1. (WO2017155890) NOVEL SMALL MOLECULE ANTIMICROBIALS
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Pub. No.: WO/2017/155890 International Application No.: PCT/US2017/020968
Publication Date: 14.09.2017 International Filing Date: 06.03.2017
IPC:
C07D 215/38 (2006.01) ,A61K 31/04 (2006.01) ,A61K 31/497 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
04
Nitro compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
Applicants:
OHIO STATE INNOVATION FOUNDATION [US/US]; 1524 North High Street Columbus, Ohio 43201, US
Inventors:
RAJASHEKARA, Gireesh; US
DEBLANCO, Esperanza Carcache; US
FUCHS, James; US
NISLOW, Corey; US
PASCALL, Melvin; US
WAN, Zilu; US
ACUNA, Ulyana Munoz; US
ANTWI, Janet; US
KUMAR, Anand; US
Agent:
SWEENEY, Patricia A.; US
MCKEE, BRUCE W.; SEASE, EDMUND J.; HANSING, MARK D.; HARTUNG, KIRK M.; NEBEL, HEIDI S.; LINK, JILL N.; JOHNSON, R. SCOTT; GILCHRIST, MICHAEL C.; MOHRHAUSER, LUKE T.; KENNEDY, JONATHAN L.; ROBERTS, BRETT J.; SMETKA, MARCUS A; LIU, XIAOHONG; McKee, Voorhees & Sease, P.L.C. 801 Grand Avenue Suie 3200 Des Moines, Iowa 50309-2721, US
Priority Data:
62/306,98611.03.2016US
62/361,84613.07.2016US
Title (EN) NOVEL SMALL MOLECULE ANTIMICROBIALS
(FR) NOUVEAUX ANTIMICROBIENS À PETITES MOLÉCULES
Abstract:
(EN) Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.
(FR) L'invention concerne des composés et des compositions de matière qui sont des antimicrobiens à petites molécules. Les composés sont choisis parmi JH-144, TH-04 ou TH-08 ou leurs combinaisons. L'invention concerne des compositions de matière qui, selon un mode de réalisation, peuvent comprendre un support, et selon d'autres modes de réalisation peuvent comprendre un excipient, un film, un biofilm ou un film comestible pharmaceutiquement acceptable. L'invention concerne également des procédés d'utilisation dans lesquels la composition peut être administrée à un sujet en ayant besoin, et dans un mode de réalisation où le sujet présente une infection bactérienne. D'autres modes de réalisation concernent la mise en contact de la composition avec une surface pour éliminer ou réduire les bactéries.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)