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1. (WO2017155857) COMPOSITIONS AND METHODS FOR ADMINISTERING PPARγ AGONISTS, SURFACTANT PEPTIDES AND PHOSPHOLIPIDS
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Pub. No.: WO/2017/155857 International Application No.: PCT/US2017/020881
Publication Date: 14.09.2017 International Filing Date: 06.03.2017
IPC:
A61K 31/4439 (2006.01) ,A61K 9/127 (2006.01) ,A61K 31/426 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
Applicants:
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER [US/US]; 1124 West Carson Street Torrance, California 90502, US
Inventors:
REHAN, Virender K.; US
TORDAY, John S.; US
WALTHER, Frans J.; US
WARING, Alan J.; US
GORDON, Larry M.; US
Agent:
NIE, Alex Y.; US
TANNER, Lorna L.; US
HIRAYAMA, Lacie C.; US
LIU, Bowen; US
NEMIROW, Joy L.; US
THAKUR, Neeta C.; US
SMITH, Lee-Ann; US
Priority Data:
62/304,84507.03.2016US
Title (EN) COMPOSITIONS AND METHODS FOR ADMINISTERING PPARγ AGONISTS, SURFACTANT PEPTIDES AND PHOSPHOLIPIDS
(FR) COMPOSITIONS ET PROCÉDÉS POUR L'ADMINISTRATION D'AGONISTES DE PPARV, PEPTIDES TENSIOACTIFS ET PHOPHOLIPIDES
Abstract:
(EN) The present disclosure provides compositions and therapies that can address both the symptoms and disorders associated with insufficient surfactant production and hyperoxia. In one embodiment, the composition can be formulated for aerosol delivery during ventilation therapy. The composition can comprise one or more of the following: a PPAR gamma agonist, a surfactant peptide, and one or more phospholipids. The compositions are formulated to provide the complementary benefits of reducing the likelihood of developing or the severity of RDS in infants, as well as protecting and promoting lung maturation in a hyperoxic environment.
(FR) La présente invention concerne des compositions et des thérapies qui peuvent aborder à la fois les symptômes et les troubles associés à la production insuffisante de tensioactifs et à l'hyperoxie. Dans un mode de réalisation, la composition peut être formulée pour une administration d'aérosol pendant une thérapie par ventilation. La composition peut comprendre un ou plusieurs des éléments suivants : un agoniste de PPAR gamma, un peptide tensioactif et un ou plusieurs phospholipides. Les compositions sont formulées pour fournir les avantages complémentaires de réduction de la probabilité de développement ou de la gravité du syndrome de détresse respiratoire du nouveau-né, ainsi que de protection et de promotion de la maturation pulmonaire dans un environnement hyperoxique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)