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1. (WO2017155846) IMMUNO-GENE COMBINATION THERAPY

Pub. No.:    WO/2017/155846    International Application No.:    PCT/US2017/020856
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 07 00:59:59 CET 2017
IPC: A61K 35/14
A61K 39/00
A61K 39/395
A61K 45/06
A61K 48/00
Applicants: THE UNIVERSITY OF PENNSYLVANIA
Inventors: STERMAN, Daniel
ALBEDA, Steven
Title: IMMUNO-GENE COMBINATION THERAPY
Abstract:
"In situ vaccination" using immuno-gene therapy has the ability to induce polyclonal anti-tumor responses directed by the patient's immune system. Patients with unresectable MPM received two intrapleural doses of a replication-defective adenoviral vector containing the human interferon-alpha (hIFN-α2b) gene (Ad.IFN) concomitant with a 14-day course of a cyclooxygenase-2 inhibitor (celecoxib), followed by standard first- or second-line cytotoxic chemotherapy. Forty subjects, ECOG PS 0 or 1, were treated: 18 received first-line pemetrexed- based chemotherapy with platinum, 22 received second-line chemotherapy with pemetrexed (n=7) or a gemcitabine-based regimen (n=15). Overall survival rate was significantly higher than historical controls in the second-line group.