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1. (WO2017155765) BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS

Pub. No.:    WO/2017/155765    International Application No.:    PCT/US2017/020303
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: A61K 31/454
A61K 31/427
A61K 31/501
C07D 417/12
Applicants: MERCK SHARP & DOHME CORP.
LIU, Weiguo
DING, Fa-Xiang
SUN, Wanying
DEJESUS, Reynalda, Keh
TANG, Haifeng
HUANG, Xianhai
JIAN, Jinlong
GUO, Yan
WANG, Hongwu
Inventors: LIU, Weiguo
DING, Fa-Xiang
SUN, Wanying
DEJESUS, Reynalda, Keh
TANG, Haifeng
HUANG, Xianhai
JIAN, Jinlong
GUO, Yan
WANG, Hongwu
Title: BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS
Abstract:
The present invention relates to bicyclic aryl monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A1, L, M, W, X, Y, Z, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a bicyclic aryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of one or more beta-lactamase inhibitor compounds.