Search International and National Patent Collections

1. (WO2017155736) MICROSCALE WHOLE BLOOD COAGULATION ASSAY PLATFORM

Pub. No.:    WO/2017/155736    International Application No.:    PCT/US2017/019846
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: G01N 15/02
G01L 9/00
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: FU, Jianping
WARD, Kevin, R.
LI, Zida
LI, Xiang
Title: MICROSCALE WHOLE BLOOD COAGULATION ASSAY PLATFORM
Abstract:
A blood clot retraction assay device and methods of measuring whole-blood clot retractive forces during coagulation are described. When placed in proximity to a micro-beam, a blood droplet attaches thereto, applying a force to the micro-beam during clot formation. Using Piezoresistive micro-beams or other Piezoresistive components disposed upon such micro-beams, the device measures retractive force of a blood droplet based upon changes in resistance. The sensitivity of such measurements allows use of small quantities of blood for measurement, between 15 microliters and 300 microliters. The device further permits continuous measurement of coagulation, allowing measurement of distinct reaction, contraction development, and fibrinolysis phases for each blood sample.