Search International and National Patent Collections

1. (WO2017155717) NOVEL CAS9 SYSTEMS AND METHODS OF USE

Pub. No.:    WO/2017/155717    International Application No.:    PCT/US2017/019640
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Feb 28 00:59:59 CET 2017
IPC: C12N 15/113
C12N 9/22
C12N 15/82
Applicants: PIONEER HI-BRED INTERNATIONAL, INC.
Inventors: CIGAN, Andrew Mark
KING, Matthew G.
LIN, Haining
YOUNG, Joshua K.
Title: NOVEL CAS9 SYSTEMS AND METHODS OF USE
Abstract:
Compositions and methods are provided for novel Cas9 systems, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single or dual guide RNAs, guide RNA elements, and Cas9 endonucleases. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell. Also provided are nucleic acid constructs and cells having an altered target site or altered polynucleotide of interest produced by the methods described herein.