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1. (WO2017155715) NOVEL CAS9 SYSTEMS AND METHODS OF USE
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Pub. No.: WO/2017/155715 International Application No.: PCT/US2017/019631
Publication Date: 14.09.2017 International Filing Date: 27.02.2017
IPC:
C12N 15/113 (2010.01) ,C12N 9/22 (2006.01) ,C12N 15/82 (2006.01)
[IPC code unknown for C12N 15/113][IPC code unknown for C12N 9/22][IPC code unknown for C12N 15/82]
Applicants:
PIONEER HI-BRED INTERNATIONAL, INC. [US/US]; 7100 N.W. 62nd Avenue P.O. Box 1014 Johnston, Iowa 50131-1014, US
Inventors:
CIGAN, Andrew Mark; US
KING, Matthew G.; US
LIN, Haining; US
YOUNG, Joshua K.; US
Agent:
VOSNIDOU, Nancy; US
Priority Data:
62/306,91611.03.2016US
Title (EN) NOVEL CAS9 SYSTEMS AND METHODS OF USE
(FR) NOUVEAUX SYSTÈMES CAS9 ET PROCÉDÉS D’UTILISATION
Abstract:
(EN) Compositions and methods are provided for novel Cas9 systems, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single or dual guide RNAs, guide RNA elements, and Cas9 endonucleases. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell. Also provided are nucleic acid constructs and cells having an altered target site or altered polynucleotide of interest produced by the methods described herein.
(FR) La présente invention concerne des compositions et des procédés destinés à de nouveaux systèmes Cas9 comprenant, sans caractère limitatif, de nouveaux complexes polynucléotide/endonucléases Cas9 guides, des ARN guides simples ou doubles, des éléments ARN guides et des endonucléases Cas9. La présente invention concerne également des procédés de modification génomique d’une séquence cible dans le génome d’une cellule, pour l’édition de gènes, et pour l’insertion d’un polynucléotide d’intérêt dans le génome d’une cellule. L'invention concerne également des constructions d'acides nucléiques et des cellules comprenant un site cible modifié ou un polynucléotide d'intérêt modifié produits par les procédés de l’invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)