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1. (WO2017155670) THREE-DIMENSIONAL ELECTRONIC SCAFFOLD FOR CARDIAC APPLICATIONS

Pub. No.:    WO/2017/155670    International Application No.:    PCT/US2017/017808
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Feb 15 00:59:59 CET 2017
IPC: C12M 1/12
A61L 27/18
A61L 27/38
A61L 27/54
A61L 27/56
B29C 67/00
C12M 1/34
C12M 3/00
B33Y 70/00
B33Y 80/00
Applicants: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
Inventors: QIAN, Fang
BORA, Mihail
DUOSS, Eric
SPADACCINI, Christopher
ZHU, Cheng
Title: THREE-DIMENSIONAL ELECTRONIC SCAFFOLD FOR CARDIAC APPLICATIONS
Abstract:
Disclosed here is a three-dimensional electronic scaffold, comprising a porous scaffold and a plurality of micro-strain gauges distributed spatially inside the porous scaffold, wherein the micro-strain gauges are adapted to detect contraction force. Also disclosed is a method comprising detecting and mapping intra-tissue cardiac contraction force of one or more cardiac cells or tissues disposed in a three-dimensional electronic scaffold, wherein the three-dimensional electronic scaffold comprises a porous scaffold and a plurality of micro-strain gauges distributed spatially inside the porous scaffold and in contact with the cardiac cells or tissues, and wherein the micro-strain gauges are adapted to detect contraction force of the cardiac cells or tissues.