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1. (WO2017155465) COMPOUND FOR USE IN THE TREATMENT AND/OR PREVENTION OF PARASITIC MEDIATED DISEASES
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Pub. No.: WO/2017/155465 International Application No.: PCT/SG2017/050109
Publication Date: 14.09.2017 International Filing Date: 08.03.2017
IPC:
A61K 31/37 (2006.01) ,A61K 36/75 (2006.01) ,A61P 33/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
366
having six-membered rings, e.g. delta-lactones
37
Coumarins, e.g. psoralen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
75
Rutaceae (Rue family)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06
Antimalarials
Applicants:
LEEWARD PACIFIC PTE LTD [SG/SG]; 207A Thomson Road Goldhill Centre Singapore 307640, SG
Inventors:
KOH, Hwee Ling; SG
TENG, Woon Chien Cecilia; SG
LEE, Ying; SG
Agent:
YUSARN AUDREY; 24 Raffles Place, #27-01 Clifford Centre, Singapore 048621, SG
Priority Data:
10201601898S11.03.2016SG
Title (EN) COMPOUND FOR USE IN THE TREATMENT AND/OR PREVENTION OF PARASITIC MEDIATED DISEASES
(FR) COMPOSÉ POUR UNE UTILISATION DANS LE TRAITEMENT ET/OU LA PRÉVENTION DE MALADIES D'ORIGINE PARASITAIRE
Abstract:
(EN) The present invention provides a compound belonging to furanocoumarin derivative having core structure (A) as given below, its pharmaceutically acceptable salt, isomer or a combination thereof for the treatment and/or prevention of a parasitic mediated disease. The present invention also provides a method for manufacturing and isolating said compound as well as method for treatment and prevention of parasitic mediated disease using said compound. In a preferred embodiment, the parasite is Plasmodium falciparum, the disease mediated by the said parasite is malaria and the furanocoumarin derivative having core structure (A) is Anisolactone.
(FR) La présente invention concerne un composé de type dérivé furanocoumarine possédant une structure de base (A) telle que présentée ci-dessous, son sel pharmaceutiquement acceptable, son isomère ou une combinaison de ces derniers, pour le traitement et/ou la prévention de maladies d'origine parasitaire. La présente invention concerne également un procédé de fabrication et d'isolement dudit composé ainsi qu'une méthode de traitement et de prévention de maladies d'origine parasitaire à l'aide dudit composé. Dans un mode de réalisation préféré, le parasite est le Plasmodium falciparum, la maladie provoquée par ledit parasite est le paludisme, et le dérivé furanocoumarine possédant une structure de base (A) est l'Anisolactone.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)