Search International and National Patent Collections

1. (WO2017155399) DOUBLE TUBULAR STRUCTURES

Pub. No.:    WO/2017/155399    International Application No.:    PCT/NL2017/050145
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C12N 5/071
B01L 3/00
Applicants: MIMETAS B.V.
Inventors: VULTO, Paul
KUREK, Dorota Malgorzata
JOORE, Adrianus Theodorus
TRIETSCH, Sebastiaan Johannes
LANZ, Henriëtte Leonore
Title: DOUBLE TUBULAR STRUCTURES
Abstract:
The present invention relates to a method of culturing and/or monitoring epithelial cells using a microfluidic cell culture system comprising a microfluidic channel network. In the method epithelial cells are lined, in the microfluidic cell culture system by cells of mesenchymal origin. The cells may form a tubular or tube-like structure, i.e. a.tube in a tube. The method allows for improved epithelial models suitable for a wide variety of applications, including but not limited to high-throughput screening and analysis of epithelium in health and disease.