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|1. (WO2017155355) ANTIBODY SPECIFICALLY BINDING TO AIMP2-DX2 PROTEIN|
|Applicants:||MEDICINAL BIOCONVERGENCE RESEARCH CENTER
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
KWON, Nam Hoon
NGUYEN THI, Thu ha
|Title:||ANTIBODY SPECIFICALLY BINDING TO AIMP2-DX2 PROTEIN|
The present invention relates to an antibody specifically binding to AIMP2-DX2 protein and, more particularly, to an antibody specifically binding to AIMP2-DX2 which recognizes, as an epitope, a polypeptide comprising an amino acid sequence represented by SEQ ID.: 1, or a fragment of the antibody, a composition for diagnosing a cancer comprising the same, and a polynucleotide and recombinant expression vector encoding the antibody, a transformed cell using the same, and a method for preparing the antibody or the fragment of the antibody. Since the antibody according to the present invention does not react with a wild-type AIMP2 protein and specifically binds to an exon2-deleted AIMP2-DX2 mutant protein, the antibody can be effectively used to confirm the presence and expression level of AIMP2-DX2 protein. AIMP2-DX2 protein is associated with pathologies, such as cancer and inflammatory diseases, etc., and is particularly overexpressed in cancer diseases, such as lung cancer, breast cancer and colorectal cancer. Therefore, the present invention can be used for developing a cancer diagnostic composition which detects AIMP2-DX2 for cancer occurrence and progression and as a biomarker.