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1. (WO2017155328) METHOD FOR PRODUCING EXTRACELLULAR MATRIX MEMBRANE DERIVED FROM BIOCOMPATIBLE PORCINE CARTILAGE CAPABLE OF REGULATING IN VIVO DECOMPOSITION RATE AND PHYSICAL PROPERTIES, AND COMPOSITION FOR PREVENTING ADHESION CONTAINING EXTRACELLULAR MATRIX DERIVED FROM PORCINE CARTILAGE AS ACTIVE INGREDIENT

Pub. No.:    WO/2017/155328    International Application No.:    PCT/KR2017/002563
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: A61L 27/36
C12N 5/077
A61L 27/50
A61L 27/52
A61L 27/56
Applicants: ATEMs CO., LTD.
에이템스 주식회사
Inventors: MIN, Byoung-Hyun
민병현
KIM, Young Jick
김영직
SONG, Bo Ram
송보람
YUN, Hee Woong
윤희웅
JEONG, Sung In
정성린
LIM, Youn-Mook
임윤묵
PARK, Jong-Seok
박종석
GWON, Hui-Jeong
권희정
Title: METHOD FOR PRODUCING EXTRACELLULAR MATRIX MEMBRANE DERIVED FROM BIOCOMPATIBLE PORCINE CARTILAGE CAPABLE OF REGULATING IN VIVO DECOMPOSITION RATE AND PHYSICAL PROPERTIES, AND COMPOSITION FOR PREVENTING ADHESION CONTAINING EXTRACELLULAR MATRIX DERIVED FROM PORCINE CARTILAGE AS ACTIVE INGREDIENT
Abstract:
The present invention relates to a method for producing an extracellular matrix membrane derived from biocompatible porcine cartilage capable of regulating an in vivo decomposition rate and physical properties, and a composition for preventing adhesion containing an extracellular matrix derived from porcine cartilage as an active ingredient. Despite high biocompatibility as a natural material, there is an application limit because an extracellular matrix of a cartilage tissue has poor physical properties such as a short decomposition time. Thus, a method for improving the physical properties through physical and chemical treatment thereof has been developed. In the present invention, an extracellular matrix derived from porcine cartilage is treated with physico-chemical methods to produce various types of biomaterials, and it has been confirmed that a cartilage-specific function is retained in spite of the physico-chemical treatment. Also, the present invention can be utilized as an anti-adhesion agent having excellent in vivo stability and an anti-adhesion effect using the extracellular matrix material derived from porcine cartilage.