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1. (WO2017155325) COMPOSITION FOR PROLIFERATION, DIFFERENTIATION PROMOTION, OR SENESCENCE INHIBITION OF STEM CELLS, CONTAINING JAK1 INHIBITOR AS ACTIVE INGREDIENT

Pub. No.:    WO/2017/155325    International Application No.:    PCT/KR2017/002552
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C12N 5/0775
A61K 35/28
Applicants: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
울산대학교 산학협력단
Inventors: KIM, Seong-Who
김승후
KIM, Sang-Yoon
김상윤
LEE, Hyang-Ju
이향주
Title: COMPOSITION FOR PROLIFERATION, DIFFERENTIATION PROMOTION, OR SENESCENCE INHIBITION OF STEM CELLS, CONTAINING JAK1 INHIBITOR AS ACTIVE INGREDIENT
Abstract:
The present invention relates to a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells, containing a JAK1 inhibitor as an active ingredient. JAK1 inhibitor-treated stem cells or JAK1 knockout stem cells, of the present invention, have an activity for decreasing senescence and increasing the survival rate of the stem cells, thereby being usable in a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells. In addition, JAK1 knockout stem cells have an activity for inhibiting or decreasing the expression of HLA-A or HLA-B, which is an immunogenicity related protein, and promoting or increasing the expression of TGF-b or HGF, which is a T cell activity inhibitory protein, thereby also being usable in the prevention or treatment of immune diseases.