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1. (WO2017155281) COMPLEX OF ADENOVIRUS AND PAMAM-PEG-ERBITUX, AND USE THEREOF

Pub. No.:    WO/2017/155281    International Application No.:    PCT/KR2017/002449
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: A61K 47/50
A61K 47/32
A61K 39/395
A61K 48/00
Applicants: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY
한양대학교 산학협력단
Inventors: YUN, Chae Ok
윤채옥
YOON, A-Rum
윤아름
Title: COMPLEX OF ADENOVIRUS AND PAMAM-PEG-ERBITUX, AND USE THEREOF
Abstract:
The present invention relates to a complex of an antitumor adenovirus coated with ErbB-PEG-PAMAM and the use thereof. When using the complex of the present invention, a tumor cell-specific gene transfer effect by an excellent tumor cell infiltration ability is excellent, hepatotoxicity is low, a blood flow retention time is prolonged. Thus, the complex of the present invention can be used as a pharmaceutical composition for the treatment of a tumor and a gene therapy agent which can be administered systemically.