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1. (WO2017155101) FLUORESCENT PROTEIN

Pub. No.:    WO/2017/155101    International Application No.:    PCT/JP2017/009759
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C07K 14/435
C07K 19/00
C12N 1/15
C12N 1/19
C12N 1/21
C12N 5/10
C12N 15/09
G01N 21/64
G01N 21/78
Applicants: OSAKA UNIVERSITY
国立大学法人大阪大学
Inventors: NAGAI Takeharu
永井健治
SHINODA Hajime
篠田肇
MATSUDA Tomoki
松田知己
MA Yuanqing
マ ユアンキン
Title: FLUORESCENT PROTEIN
Abstract:
Provided is a greenish yellow fluorescent protein having high pH stability (reduced pH sensitivity). The fluorescent protein in one or a plurality of embodiments has an amino acid sequence in which at least the mutation below is introduced at the 2nd through 225th sequence of the amino acid sequence represented by SEQ ID NO: 1. Here, the mutation is selected from the group consisting of F149T or S or A, L158T or S or A, H160T or S or A, Y174T or S or A, Y192T or S or A, and combinations of 2 to 5 of the above mutations.