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1. (WO2017155044) SECONDARY MUTATION DETECTION METHOD AND SECONDARY MUTATION DETECTION KIT

Pub. No.:    WO/2017/155044    International Application No.:    PCT/JP2017/009501
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C12N 15/00
C12Q 1/68
Applicants: NATIONAL CANCER CENTER
国立研究開発法人国立がん研究センター
Inventors: KOHNO Takashi
河野 隆志
GOTO Koichi
後藤 功一
Title: SECONDARY MUTATION DETECTION METHOD AND SECONDARY MUTATION DETECTION KIT
Abstract:
The present invention provides: a method for detecting a secondary mutation in RET tyrosine kinase, whereby it becomes possible to predict or recognize the occurrence of treatment resistance in a treatment with a RET tyrosine kinase inhibitor and it also becomes possible to provide further treatment selectivity; and a secondary mutation detection kit. The method for detecting a secondary mutation according to the present invention is a method for detecting a secondary mutation in RET tyrosine kinase in a sample from a patient who has undergone a treatment with an inhibitor of the RET tyrosine kinase, said method being characterized by comprising a step of detecting an S904F mutation in the RET tyrosine kinase in the sample.