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1. (WO2017155019) PROTEIN ADSORPTION INHIBITOR AND METHOD FOR INHIBITING ADSORPTION OF PROTEIN
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Pub. No.: WO/2017/155019 International Application No.: PCT/JP2017/009405
Publication Date: 14.09.2017 International Filing Date: 09.03.2017
IPC:
G01N 33/531 (2006.01) ,C08F 20/26 (2006.01) ,C08J 7/04 (2006.01) ,G01N 33/48 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
F
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
20
Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide, or nitrile thereof
02
Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
10
Esters
26
Esters containing oxygen in addition to the carboxy oxygen
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
J
WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
7
Chemical treatment or coating of shaped articles made of macromolecular substances
04
Coating
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
Applicants:
国立大学法人山形大学 NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITY [JP/JP]; 山形県山形市小白川町一丁目4番12号 1-4-12, Kojirakawa-machi, Yamagata-shi, Yamagata 9908560, JP
日油株式会社 NOF CORPORATION [JP/JP]; 東京都渋谷区恵比寿四丁目20-3 20-3, Ebisu 4-chome, Shibuya-ku, Tokyo 1506019, JP
Inventors:
田中 賢 TANAKA Masaru; JP
山田 智 YAMADA Satoshi; JP
坂元 伸行 SAKAMOTO Nobuyuki; JP
Agent:
小林 浩 KOBAYASHI Hiroshi; JP
潮 太朗 USHIO Taro; JP
鈴木 康仁 SUZUKI Yasuhito; JP
Priority Data:
2016-04682910.03.2016JP
Title (EN) PROTEIN ADSORPTION INHIBITOR AND METHOD FOR INHIBITING ADSORPTION OF PROTEIN
(FR) INHIBITEUR D’ADSORPTION DE PROTÉINE ET PROCÉDÉ D’INHIBITION D’ADSORPTION DE PROTÉINE
(JA) 蛋白質吸着抑制剤および蛋白質吸着抑制の方法
Abstract:
(EN) The present invention addresses the problem of providing a protein adsorption inhibitor which can inhibit the non-specific adsorption of a protein, e.g., an antibody and an enzyme, onto a solid surface of a base material, e.g., an immune reaction vessel and a measurement tool, at a high level and which has improved wet-scrub resistance. The problem can be solved by a protein adsorption inhibitor which contains a water-soluble acrylic polymer (P) as an active ingredient, wherein the water-soluble acrylic polymer (P) contains a repeating constituent unit [A] represented by formula (1), has a number average molecular weight of 5,000 to 250,000 and has an LCST of 25 to 45ºC. [R1 represents a hydrogen atom or a methyl group; R2 represents a methyl group or an ethyl group; and n means the average number of moles of an oxyalkylene group added and represents 2 to 3.]
(FR) La présente invention aborde le problème de fourniture d’un inhibiteur d'adsorption de protéine qui peut inhiber l'adsorption non spécifique d'une protéine, par exemple un anticorps et une enzyme, sur une surface solide d'un matériau de base, par exemple, une cuve de réaction immunitaire et un outil de mesure, à un taux élevé et qui présente une résistance améliorée au frottement humide. Le problème peut être résolu par un inhibiteur d'adsorption de protéine qui contient un polymère acrylique soluble dans l'eau (P) en tant que substance active, le polymère acrylique soluble dans l'eau (P) contenant un motif constitutif de répétition [A] représenté par la formule (1), a un poids moléculaire moyen en nombre de 5 000 à 250 000 et a un LCST de 25 à 45°C. [R1 représente un atome d'hydrogène ou un groupe méthyle ; R2 représente un groupe méthyle ou un groupe éthyle ; et n représente le nombre moyen de moles d'un groupe oxyalkylène ajouté et représente 2 à 3.]
(JA) 抗体や酵素といった蛋白質が免疫反応容器や測定器具等の基材の固相表面に非特異的に吸着することを高いレベルで抑制し、さらに耐洗浄性を向上させた蛋白吸着抑制剤を提供する。 下記の式(1)で表される繰り返し構成単位[A]を含み、数平均分子量が5,000~250,000であり、LCSTが25~45℃である水溶性アクリル重合体(P)を有効成分として含有する、蛋白質吸着抑制剤により、上記課題は解決された。[Rは水素原子またはメチル基であり、Rはメチル基またはエチル基であり、nはオキシアルキレン基の平均付加モル数で2~3である。]
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)