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1. (WO2017154822) SUSTAINED DRUG RELEASE SHEET FOR TREATING NERVE DAMAGE

Pub. No.:    WO/2017/154822    International Application No.:    PCT/JP2017/008730
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 07 00:59:59 CET 2017
IPC: A61K 9/70
A61K 31/714
A61K 35/36
A61K 38/18
A61K 45/00
A61K 47/34
A61K 47/36
A61P 25/00
A61P 25/02
Applicants: OSAKA UNIVERSITY
国立大学法人大阪大学
NATIONAL INSTITUTE FOR MATERIALS SCIENCE
国立研究開発法人物質・材料研究機構
NIPPON ZOKI PHARMACEUTICAL CO., LTD.
日本臓器製薬株式会社
Inventors: TANAKA, Hiroyuki
田中 啓之
OKADA, Kiyoshi
岡田 潔
YOSHIKAWA, Hideki
吉川 秀樹
SUZUKI Koji
鈴木 浩司
EBARA Mitsuhiro
荏原 充宏
Title: SUSTAINED DRUG RELEASE SHEET FOR TREATING NERVE DAMAGE
Abstract:
Provided is a sustained release sheet that includes a drug for treating nerve damage, wherein the sheet is applied to a nerve damage site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve damage site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve damage is a sheet comprising a nonwoven fabric that is formed from nanofibers which include a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve damage site to promote nerve regeneration.