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1. (WO2017154767) ORGANIC NITROXIDE RADICAL COMPOUND AND METHOD FOR PRODUCING SAME, AND NANO EMULSION PARTICLES AND USE THEREOF
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Pub. No.: WO/2017/154767 International Application No.: PCT/JP2017/008469
Publication Date: 14.09.2017 International Filing Date: 03.03.2017
IPC:
C07D 207/46 (2006.01) ,A61K 9/107 (2006.01) ,A61K 47/34 (2017.01) ,A61K 49/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46
with hetero atoms directly attached to the ring nitrogen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
20
containing free radicals
Applicants:
国立大学法人京都大学 KYOTO UNIVERSITY [JP/JP]; 京都府京都市左京区吉田本町36番地1 36-1, Yoshida-honmachi, Sakyo-ku, Kyoto-shi, Kyoto 6068501, JP
Inventors:
田村 類 TAMURA, Rui; JP
名倉 康太 NAGURA, Kota; JP
Agent:
特許業務法人三枝国際特許事務所 SAEGUSA & PARTNERS; 大阪府大阪市中央区道修町1-7-1 北浜TNKビル Kitahama TNK Building, 1-7-1, Doshomachi, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Priority Data:
2016-04445008.03.2016JP
Title (EN) ORGANIC NITROXIDE RADICAL COMPOUND AND METHOD FOR PRODUCING SAME, AND NANO EMULSION PARTICLES AND USE THEREOF
(FR) COMPOSÉ ORGANIQUE RADICALAIRE DE NITROXYDE ET PROCÉDÉ POUR SA PRODUCTION ET NANOPARTICULES D'ÉMULSION ET LEUR UTILISATION
(JA) 有機ニトロキシドラジカル化合物、その製造方法、ナノエマルション粒子及びその用途
Abstract:
(EN) The purpose of the present invention is to provide: nano emulsion particles which can be used as a metal-free contrast agent for MRI or the like; and an organic nitroxide radical compound which makes it possible to easily prepare the nano emulsion particles. An organic nitroxide radical compound represented by formula (1) (wherein R1 represents a linear alkyl group having 10 to 26 carbon atoms); and nano emulsion particles each of which is composed of the organic nitroxide radical compound and a nonionic surfactant at a molar ratio of 0.8:1 to 1.2:1 and each of which has a nitroxide radical enclosed therein.
(FR) Le but de la présente invention concerne : des nanoparticules d'émulsion qui peuvent être utilisées en tant qu'agent de contraste sans métal pour une IRM ou similaire ; et un composé organique radicalaire de nitroxyde qui permet de préparer facilement les nanoparticules d'émulsion. L'invention concerne un composé organique radicalaire de nitroxyde représenté par la formule (1) (dans laquelle R1 représente un groupe alkyle linéaire comprenant 10 à 26 atomes de carbone) ; et des nanoparticules d'émulsion dont chacune est composée du composé organique radicalaire de nitroxyde et d'un tensioactif non ionique à un rapport molaire de 0,8:1 à 1,2:1 et dont chacune contient un radical de nitroxyde enfermé en son sein.
(JA) MRI等のメタルフリー造影剤として利用可能なナノエマルション粒子、及び該ナノエマルション粒子を容易に調製することができる有機ニトロキシドラジカル化合物を提供すること。 式(1)(式中、Rは、炭素数10~26の直鎖アルキル基を示す。)で表される有機ニトロキシドラジカル化合物、及び該有機ニトロキシドラジカル化合物と非イオン性界面活性剤とが0.8:1から1.2:1のモル比で構成され、ニトロキシドラジカルが内包されている、ナノエマルション粒子。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)