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1. (WO2017154026) 4BETA-AMIDOTRIAZOLE LINKED PODOPHYLLOTOXIN DERIVATIVES AS POTENTIAL ANTICANCER AGENTS

Pub. No.:    WO/2017/154026    International Application No.:    PCT/IN2017/050088
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C07D 493/04
A61K 31/4439
A61K 31/4192
A61K 31/496
A61P 35/00
A61P 31/12
Applicants: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
Inventors: KAMAL, Ahmed
REDDY, Velma Ganga
SUBBARAO, Ayinampudi Venkata
RIYAZ, Syed
NAYAK, Vadithe Lakshma
TAJ, Shaik
Title: 4BETA-AMIDOTRIAZOLE LINKED PODOPHYLLOTOXIN DERIVATIVES AS POTENTIAL ANTICANCER AGENTS
Abstract:
The present invention relates to a compound of general formula (A). The invention provides asynthesis of new 4β-amidotriazole linked podophyllotoxin derivatives of general formulae 8a-z to 9a-z useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. Wherein n = 0,1 and R1-R5 = [H, CI, F, CH3, OCH3, 3,4(-OCH2O-), CF3, OCF3, m-OC6H5, OH]