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1. (WO2017153956) USES OF DENTAL PULP STEM CELLS EXPRESSING MESENCHYMAL AND NEURONAL MARKERS AND COMPOSITIONS THEREOF TO TREAT NEUROLOGICAL DISEASE

Pub. No.:    WO/2017/153956    International Application No.:    PCT/IB2017/051404
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: A61K 35/32
A61P 25/00
A61P 25/08
A61P 25/14
A61P 25/16
A61P 25/28
Applicants: AVITA INTERNATIONAL LTD.
FUNDAÇÃO BUTANTAN
Inventors: KERKIS, Irina
VALVERDE WENCESLAU, Cristiane
Title: USES OF DENTAL PULP STEM CELLS EXPRESSING MESENCHYMAL AND NEURONAL MARKERS AND COMPOSITIONS THEREOF TO TREAT NEUROLOGICAL DISEASE
Abstract:
The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.