Search International and National Patent Collections

1. (WO2017153954) HUMAN CYTOMEGALOVIRUS GB POLYPEPTIDE

Pub. No.:    WO/2017/153954    International Application No.:    PCT/IB2017/051401
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C07K 14/005
Applicants: PFIZER INC.
Inventors: CHI, Xiaoyuan Sherry
YANG, Xinzhen
Title: HUMAN CYTOMEGALOVIRUS GB POLYPEPTIDE
Abstract:
The present invention relates to a polypeptide that includes at least one mutation in the fusion loop 1 region and/or in the fusion loop 2 region and/or in the furin-like cleavage site of a human cytomegalovirus gB polypeptide. In one embodiment, the polypeptide undergoes a structural conformation change in response to pH change.