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1. (WO2017153953) USE OF ANTI-MCAM ANTIBODIES FOR TREATMENT OR PROPHYLAXIS OF GRANULOMATOUS LUNG DISEASES

Pub. No.:    WO/2017/153953    International Application No.:    PCT/IB2017/051400
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C07K 16/30
G01N 33/48
Applicants: PROTHENA BIOSCIENCES LIMITED
Inventors: FLANAGAN, Kenneth
HAMZEH, Nabeel
Title: USE OF ANTI-MCAM ANTIBODIES FOR TREATMENT OR PROPHYLAXIS OF GRANULOMATOUS LUNG DISEASES
Abstract:
The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain and pharmaceutical compositions and pharmaceutical formulations incorporating the same for use in treatment or prophylaxis of chronic beryllium disease (CBD), Blau syndrome or hot tub lung disease, methods of generating such antibodies, and their use in the manufacture of medicaments for treatment of granulomatous lung diseases.