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|1. (WO2017153950) INHIBITORS OF INFLUENZA VIRUS NUCLEASE (POLYMERASE COMPLEX)|
|Applicants:||BIOTECH INNOVATIONS SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ
|Title:||INHIBITORS OF INFLUENZA VIRUS NUCLEASE (POLYMERASE COMPLEX)|
The 4-hydroxyphenyl-2-oxoethyl carboxylic derivatives of the general formula: R1-A- R2, wherein the core A is: Formula (I) and R1 is phenyl substituted with two C1-C4 alkyl, 1,3-benzodioxolyl or bicyclo[3.3.1]nonanyl and R2 is H, hydroxyl, amino group optionally substituted with carbonyl- C1-C4 alkyl or amide optionally substituted by C1-C4 alkyl; as well as their pharmaceutically acceptable salts, solvates, polymorphs, co-drugs, cocrystals, prodrugs, tautomers, racemates, enantiomers or diastereomers, or mixtures thereof; as endonucleolytic activity inhibitors in viruses with segmented negative- sense RNA genome for use as an antiviral drug. The invention further includes the use of the said derivative for manufacturing of a medicine for treatment, alleviation or prophylaxis of viral infection caused by viruses from Orthomyxoviridae family among others, including influenza and its complications, as well as for combination therapy with neuraminidase inhibitor, amantadine, neuraminidase, amantadine or rimantadine, or any other combination thereof.