Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017153892) SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF β-LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/153892 International Application No.: PCT/IB2017/051296
Publication Date: 14.09.2017 International Filing Date: 06.03.2017
IPC:
C07D 499/44 (2006.01) ,C07D 501/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
499
Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
21
with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
44
Compounds with an amino radical acylated by carboxylic acids, attached in position 6
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
501
Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14
Compounds having a nitrogen atom directly attached in position 7
16
with a double bond between positions 2 and 3
20
7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Applicants:
BONOMI, Paolo [IT/FR]; FR
Inventors:
BONOMI, Paolo; FR
Agent:
DE GREGORI, Antonella; IT
CALOGERO, Ida; IT
Priority Data:
UA2016A00144308.03.2016IT
Title (EN) SYNTHESIS PROCESS OF PRECURSORS OF DERIVATIVES OF β-LACTAM NUCLEI AND PRECURSORS AND DERIVATIVES THEREOF
(FR) PROCÉDÉ DE SYNTHÈSE DE PRÉCURSEURS DE DÉRIVÉS DE NOYAU Β-LACTAME ET PRÉCURSEURS ET DÉRIVÉS DE CEUX-CI
Abstract:
(EN) A synthesis process of precursors of derivatives of beta-lactam compounds, said beta-lactam compounds being selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, comprising the following steps: a) protection of the amine group of the beta-lactam compound, selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, through the formation of a carbamate by reaction with a dicarbonate; b) esterification of the carboxyl group in position 2 of the beta-lactam compound obtained in step a) by reaction with propargyl alcohol.
(FR) L'invention concerne un procédé de synthèse de précurseurs de dérivés de composés bêta-lactame, lesdits composés beta-lactame étant sélectionnés parmi l'acide 6-aminopénicillanique et l'acide 7-aminocéphalosporanique, de préférence l'acide 6-aminopénicillanique, comprenant les étapes suivantes : a) protection du groupe amine du composé beta-lactame, sélectionné parmi l'acide 6-aminopénicillanique et l'acide 7-aminocéphalosporanique, de préférence de l'acide 6-aminopénicillanique, par la formation d'un carbamate par réaction avec un dicarbonate ; b) estérification du groupe carboxyle en position 2 du composé de beta-lactame obtenu à l'étape a) par réaction avec de l'alcool propargylique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Italian (IT)