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1. (WO2017153822) RESINATES OF PHARAMCEUTICALLY ACCEPTABLE SALTS OF TOFACITINIB SUCH AS TOFACITINIB CITRATE, FOR TASTE MASKING

Pub. No.:    WO/2017/153822    International Application No.:    PCT/IB2016/055491
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Sep 16 01:59:59 CEST 2016
IPC: A61K 9/20
C07D 211/56
C07D 487/04
Applicants: UNICHEM LABORATORIES LIMITED
Inventors: SATHE, Milind Vinayak
PHALDESAI, Saiesh Purushottam
PIMPLE, Srikant V
Title: RESINATES OF PHARAMCEUTICALLY ACCEPTABLE SALTS OF TOFACITINIB SUCH AS TOFACITINIB CITRATE, FOR TASTE MASKING
Abstract:
The present invention relates to resinates of pharmaceutically acceptable salts of Tofacitinib such as Tofacitinib Citrate, fast disintegrating and or quick release pharmaceutical compositions comprising the said resinates and process for the preparation of resinates and compositions. The resin used to prepare the resinate is selected from copolymers of methacrylic acid and divinylbenzene, cross linked polymer of methacrylic acid and divinylbenzene, sulphonated copolymers of styrene and divinylbenzene. Ion exchange resin is contacted with the solution of Tofacitinib citrate under controlled pH in order to form the resinate. The resinate has versatile use in making of pharmaceutical preparations. Few such pharmaceutical preparations are Tablets, capsules, dry syrups, suspensions, lozenges, films.