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1. (WO2017153821) RESINATES OF TOFACITINIB FOR TASTE MASKING
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Pub. No.: WO/2017/153821 International Application No.: PCT/IB2016/055490
Publication Date: 14.09.2017 International Filing Date: 15.09.2016
IPC:
A61K 9/20 (2006.01) ,C07D 211/56 (2006.01) ,C07D 487/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
UNICHEM LABORATORIES LIMITED [IN/IN]; Unichem Bhavan, Prabhat Estate, Off. S. V. Road, Jogeshwari (W), Mumbai Maharashtra 400 102, IN
Inventors:
SATHE, Milind Vinayak; IN
PHALDESAI, Saiesh Purushottam; IN
PIMPLE, Srikant V; IN
Agent:
KHURANA & KHURANA, ADVOCATES & IP ATTORNEYS; E-13, UPSIDC, Site-IV, Behind-Grand Venice Kasna Road, Greater Noida, National Capital Region Uttar Pradesh 201310, IN
Priority Data:
20162100795308.03.2016IN
Title (EN) RESINATES OF TOFACITINIB FOR TASTE MASKING
(FR) RÉSINATES DE TOFACITINIB DESTINÉES AU MASQUAGE DU GOÛT
Abstract:
(EN) The present invention relates to resinates of Tofacitinib. The invention also relates to taste masked, stable and readily dispersible resinates of Tofacitinib, rapidly disintegrating and or quick release taste masked pharmaceutical compositions comprising the said resinates and process for the preparation of resinates and compositions. In order to form the resinate, the resin is selected from copolymers of methacrylic acid and divinylbenzene, cross linked polymer of methacrylic acid and divinylbenzene, sulphonated copolymers of styrene and divinylbenzene. In order to form the resinate, Ion exchange resin is contacted with the solution of Tofacitinib prepared in nonaromatic solvent. The resinate is useful to formulate different pharmaceutical dosage forms such as Tablets, Capsule, drysyrups.
(FR) La présente invention concerne des résinates de tofacitinib. L’invention concerne également des résinates de tofacitinib au goût masqué, stables et aisément dispersibles, des compositions pharmaceutiques au goût masqué à désintégration rapide et/ou à libération rapide comprenant lesdits résinates et un procédé de préparation des résinates et des compositions. Afin de former le résinate, la résine est choisie parmi des copolymères d'acide méthacrylique et de divinylbenzène, un polymère réticulé d'acide méthacrylique et de divinylbenzène, des copolymères sulfonés de styrène et de divinylbenzène. Afin de former le résinate, une résine échangeuse d'ions est mise en contact avec la solution de tofacitinib préparée dans un solvant non aromatique. Le résinate sert à formuler différentes formes posologiques pharmaceutiques telles que des comprimés, des capsules, des sirops secs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)