Search International and National Patent Collections

1. (WO2017153789) BENZO[B]THIOPHENE DERIVATIVES AND THEIR USE FOR THE INHIBITION OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES (FGFRS) FOR THE USE OF NEO- AND HYPERPLASIA THERAPIES

Pub. No.:    WO/2017/153789    International Application No.:    PCT/HU2016/050059
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Nov 29 00:59:59 CET 2016
IPC: C07D 333/68
C07D 409/12
C07D 417/12
A61K 31/4436
A61P 35/00
Applicants: VICHEM CHEMIE KUTATÓ KFT.
Inventors: GREFF, Zoltán
KÉRI, György
ÖRFI, László
VÁLYI-NAGY, István Tibor
BÁNHEGYI, Péter
MARKÓ, Péter
ZSÁKAI, Lilian
SZOKOL, Bálint
SZÁNTAI-KIS, Csaba
Title: BENZO[B]THIOPHENE DERIVATIVES AND THEIR USE FOR THE INHIBITION OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES (FGFRS) FOR THE USE OF NEO- AND HYPERPLASIA THERAPIES
Abstract:
The present invention relates to benzo[b]thiophene derivatives of general formula (I) and pharmaceutically acceptable salts, solvates, hydrates, stereoisomeric and polymorphic forms thereof wherein R1 is selected from the group of hydrogen; hydroxyl; substituted or unsubstituted heterocyclyl; optionally substituted amino; X, Y and Z are selected independently from the followings: CH (methine), nitrogen; R2, R3, R4 and R5 may stand for e.g. hydrogen, halogen, hydroxyl, alkyl, alkenyl, alkynyl, alkoxy and amino. The invention also relates to the use of them as of medication, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluent, especially for the inhibition Fibroblast Growth Factor Receptor kinases (FGFR's), e.g. for the treatment of cancer.