Search International and National Patent Collections

1. (WO2017153779) LIPIDS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS

Pub. No.:    WO/2017/153779    International Application No.:    PCT/GB2017/050664
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C07C 217/28
A61K 47/54
A61P 35/00
Applicants: RYBOQUIN COMPANY LTD
Inventors: HAILES, Helen, Claire
TABOR, Alethea, Bernice
MOHD MUSTAPA, Mohd, Firouz
HART, Stephen, Lewis
TAGALAKIS, Aristides
Title: LIPIDS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS
Abstract:
A lipid comprising a tri-chain cation of formula (la) having a cationic head group and three C12-24 hydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated with a co-lipid) into a LPD complex.