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1. (WO2017153774) PRENYLATION ASSAY

Pub. No.:    WO/2017/153774    International Application No.:    PCT/GB2017/050659
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C12Q 1/48
Applicants: NIGHTSTARX LIMITED
Inventors: MACLAREN, Robert E.
MOREIRA PATRICIO, Maria Ines
Title: PRENYLATION ASSAY
Abstract:
A method for determining the activity of Rab escort protein 1 (REP1) comprising the steps: (a) providing a sample comprising REP1; (b) contacting the sample of step (a) with Rab6a, Rab geranylgeranyltransferase (Rab GGTase) and a lipid donor substrate; and (c) detecting the lipidated Rab6a product.