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1. (WO2017153607) NEW IMMUNOREGULATORY CELLS AND METHODS FOR THEIR PRODUCTION
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Pub. No.: WO/2017/153607 International Application No.: PCT/EP2017/055839
Publication Date: 14.09.2017 International Filing Date: 13.03.2017
IPC:
C12N 5/0786 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0786
Monocytes; Macrophages
Applicants:
FROPHARM GMBH [DE/DE]; Flughafenstr. 52 B 22335 Hamburg, DE
Inventors:
HUTCHINSON, James; DE
GEISSLER, Edward; DE
Agent:
UEXKÜLL & STOLBERG PARTNERSCHAFT VON PATENT- UND RECHTSANWÄLTEN MBB; Beselerstr. 4 22607 Hamburg, DE
Priority Data:
16159985.711.03.2016EP
Title (EN) NEW IMMUNOREGULATORY CELLS AND METHODS FOR THEIR PRODUCTION
(FR) NOUVELLES CELLULES IMMUNORÉGULATRICES ET LEURS PROCÉDÉS DE PRODUCTION
Abstract:
(EN) The present invention relates to novel immunoregulatory macrophage cells which are useful in the treatment of different immunological and non-immunological diseases and conditions. The cells are characterized by a specific marker and activity pattern which distinguishes them from other cells. The invention also provides a process for preparing the immunoregulatory macrophage cells from blood monocytes. In a still further aspect, the invention relates to a pharmaceutical composition comprising the immunoregulatory macrophagecells of the invention or a sub-cellular fraction thereof. A process for preparing a sub-cellular fraction of an immunoregulatory macrophage cell of the invention is also provided.
(FR) La présente invention concerne de nouvelles cellules macrophages immunorégulatrices qui sont utiles dans le traitement de différents états et maladies immunologiques et non immunologiques. Les cellules sont caractérisées par un marqueur et un profil d'activité spécifiques qui les distinguent des autres cellules. L'invention décrit également un procédé de préparation des cellules macrophages immunorégulatrices à partir de monocytes sanguins. Dans encore un aspect supplémentaire, l'invention concerne une composition pharmaceutique comprenant les cellules macrophages immunorégulatrices de l'invention ou leur fraction sous-cellulaire. Un procédé de préparation d'une fraction sous-cellulaire d'une cellule macrophage immunorégulatrice de l'invention est également décrit.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)