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1. (WO2017153606) NUCLEIC ACID CONSTRUCTS AND VECTORS FOR ONCOSELECTIVE EXPRESSION OF A TRANSGENE

Pub. No.:    WO/2017/153606    International Application No.:    PCT/EP2017/055836
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 14 00:59:59 CET 2017
IPC: A61K 35/761
C12N 15/85
C12N 15/86
Applicants: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA)
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)
Inventors: MÉNDEZ DE LA IGLESIA, Raúl
FILLAT FONTS, Cristina
VILLANUEVA VERDEJO, Eneko
Title: NUCLEIC ACID CONSTRUCTS AND VECTORS FOR ONCOSELECTIVE EXPRESSION OF A TRANSGENE
Abstract:
The invention relates to a nucleic acid construct comprising polynucleotide of interest and an untranslated 3' sequence including at least two cytoplasmic polyadenylation elements. The invention also relates to vectors, viral particles, cells and pharmaceutical compositions comprising said nucleic acid construct, and to their use for inducing selective expression of a polynucleotide in a tumor cell, and said nucleic acid construct for use in medicine and in the treatment of cancer.