Search International and National Patent Collections
|1. (WO2017153605) PROCESS FOR PREPARATION OF BEADS FOR IMAGING|
|Applicants:||STICHTING KATHOLIEKE UNIVERSITEIT
FIGDOR, Carl Gustav
DE VRIES, Ingrid Jolanda Monique
|Title:||PROCESS FOR PREPARATION OF BEADS FOR IMAGING|
The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohoi and optionally a metal compound, comprising the steps of: a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant comprising polyvinylalcohoi under sonication to obtain a second liquid mixture, c) maintaining the sonication of the second liquid mixture while cooling, d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, e) separating the beads from the suspension and preparing a water suspension of the beads and f) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. The invention further relates to beads having close F-H20 interactions, which are suitable for imaging purposes.