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1. (WO2017153605) PROCESS FOR PREPARATION OF BEADS FOR IMAGING

Pub. No.:    WO/2017/153605    International Application No.:    PCT/EP2017/055827
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 14 00:59:59 CET 2017
IPC: A61K 49/00
A61K 49/18
A61K 49/22
G01N 29/04
G01N 29/24
G01N 24/08
Applicants: STICHTING KATHOLIEKE UNIVERSITEIT
Inventors: SRINIVAS, Mangala
KOSHKINA, Olga
FIGDOR, Carl Gustav
DE VRIES, Ingrid Jolanda Monique
Title: PROCESS FOR PREPARATION OF BEADS FOR IMAGING
Abstract:
The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohoi and optionally a metal compound, comprising the steps of: a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant comprising polyvinylalcohoi under sonication to obtain a second liquid mixture, c) maintaining the sonication of the second liquid mixture while cooling, d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, e) separating the beads from the suspension and preparing a water suspension of the beads and f) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. The invention further relates to beads having close F-H20 interactions, which are suitable for imaging purposes.