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1. (WO2017153595) ULTRASOUND METHOD

Pub. No.:    WO/2017/153595    International Application No.:    PCT/EP2017/055741
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C12N 15/63
A61N 5/06
A61K 49/00
Applicants: INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA (IST AUSTRIA)
Inventors: JANOVJAK, Harald
MORRI, Maurizio
HERNANDEZ, Laura Rodriguez
Title: ULTRASOUND METHOD
Abstract:
A method of regulating at least one cellular process in one or more cells by exposing the one or more cells to ultrasound, characterised in that the method comprises either (a) introducing into the one or more cells a construct comprising a regulatory transgene capable of regulating the at least one cellular process operably linked to a light-inducible control sequence and (b) inducing the expression of the regulatory transgene using sonoluminescence (SL) or sonochemiluminescence (SCL); or (i) contacting the one or more cells with one or more light-sensitive proteins capable of regulating the at least one cellular process and (ii) regulating the function of the one or more proteins using sonoluminescence or sonochemiluminescence.