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1. (WO2017153546) METHOD FOR DETERMINING THE RISK OF RECURRENCE OF AN ESTROGEN RECEPTOR-POSITIVE AND HER2-NEGATIVE PRIMARY MAMMARY CARCINOMA UNDER AN ENDOCRINE THERAPY
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Pub. No.: WO/2017/153546 International Application No.: PCT/EP2017/055601
Publication Date: 14.09.2017 International Filing Date: 09.03.2017
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
MYRIAD INTERNATIONAL GMBH [DE/DE]; Building S19 Nattermannallee 1 50829 Cologne, DE
Inventors:
WEBER, Karsten; DE
SCHEER, Marsel; DE
PETRY, Christoph; DE
Agent:
DOMPATENT VON KREISLER SELTING WERNER - PARTNERSCHAFT VON PATENTANWÄLTEN UND RECHTSANWÄLTEN MBB; Deichmannhaus am Dom Bahnhofsvorplatz 1 50667 Köln, DE
Priority Data:
16159481.709.03.2016EP
Title (EN) METHOD FOR DETERMINING THE RISK OF RECURRENCE OF AN ESTROGEN RECEPTOR-POSITIVE AND HER2-NEGATIVE PRIMARY MAMMARY CARCINOMA UNDER AN ENDOCRINE THERAPY
(FR) PROCÉDÉ DE DÉTERMINATION DU RISQUE DE RÉCURRENCE D'UN CARCINOME MAMMAIRE PRIMAIRE POSITIF AU RÉCEPTEUR DES ŒSTROGÈNES ET NÉGATIF HER2 SOUS THÉRAPIE ENDOCRINIENNE
Abstract:
(EN) Provided herein are methods for predicting a result relating to breast cancer in a patient, the method comprising (a) determining the RNA expression levels of three or more of the following 8 genes in a tumor sample from the patient: UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST and MGP; and (b) mathematically combining the expression level values for the genes of the mentioned set to obtain a combined score, the combined score indicating a prognosis for the patient, wherein the RNA expression level values have at least in part not been normalized before the mathematical combination.
(FR) La présente invention décrit des procédés de prédiction d'un résultat lié à un cancer du sein chez un patient, le procédé comprenant (a) la détermination des niveaux d'expression de l'ARN de trois des 8 gènes suivants ou plus dans un échantillon de tumeur provenant du patient : UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST et MGP; et (b) la combinaison de manière mathématique des valeurs de niveau d'expression concernant les gènes de l'ensemble mentionné afin d'obtenir un score combiné, le score combiné indiquant un prognostique pour le patient, les valeurs de niveau d'expression d'ARN n'ayant au moins en partie pas été normalisées avant la combinaison mathématique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)