Search International and National Patent Collections

1. (WO2017153497) INCREASING AQUEOUS SOLUBILITY OF BECLOMETHASONE DIPROPIONATE BY FORMATION OF CO-CRYSTALS WITH CO-CRYSTAL FORMER

Pub. No.:    WO/2017/153497    International Application No.:    PCT/EP2017/055489
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: C07J 5/00
Applicants: UNIVERSITY OF MALTA
Inventors: VELLA-ZARB, Liana
BAISCH, Ulrich
BONELLO, Antonia
Title: INCREASING AQUEOUS SOLUBILITY OF BECLOMETHASONE DIPROPIONATE BY FORMATION OF CO-CRYSTALS WITH CO-CRYSTAL FORMER
Abstract:
The invention provides a co-crystal, which co-crystal comprises beclomethasone dipropionate and a co-crystal former, which co-crystal former is adipic acid, maleic acid or isonicotinic acid. The invention also concerns a pharmaceutical composition comprising the co-crystal, various uses of the co-crystal, a process for producing the co-crystal, and a precursor composition for use in preparing the co-crystal.