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1. (WO2017153471) NEW STABLE SOLVATE CRYSTALLINE FORMS OF ELUXADOLINA

Pub. No.:    WO/2017/153471    International Application No.:    PCT/EP2017/055439
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: C07D 233/64
A61K 31/625
A61P 1/06
A61P 1/12
Applicants: EUTICALS S.P.A.
Inventors: PESENTI, Cristina
MOLTENI, Marco
LIVIERI, Alessandro
Title: NEW STABLE SOLVATE CRYSTALLINE FORMS OF ELUXADOLINA
Abstract:
Two new stable non stoichiomeric crystalline solvate forms of Eluxadoline with 4-methylpentan-2-one or methyl terf-butylether are described as well as the process for the production of the same. The solvate form with 4-methylpentan-2-one is defined as "Eluxadoline form gamma" whereas the solvate with methyl terfbutylether is defined as "Eluxadoline form delta". Form gamma may be obtained by slurrying Eluxadoline amorphous form in 4-methylpentan-2-one; form delta may be obtained by slurrying Eluxadoline form gamma in methyl terf-butylether.