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1. (WO2017153465) METHODS FOR PROGNOSIS AND TREATMENT OF COLORECTAL CANCER
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Pub. No.: WO/2017/153465 International Application No.: PCT/EP2017/055428
Publication Date: 14.09.2017 International Filing Date: 08.03.2017
IPC:
G01N 33/574 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
UNIVERSITY OF LIMERICK [IE/IE]; Plassey Technology Park Limerick, IE
Inventors:
KIELY, Patrick; IE
DOWLING, Catriona; IE
Agent:
MURGITROYD & COMPANY; Scotland House 165-169 Scotland Street Glasgow Strathclyde G5 8PL, GB
Priority Data:
16159351.209.03.2016EP
Title (EN) METHODS FOR PROGNOSIS AND TREATMENT OF COLORECTAL CANCER
(FR) MÉTHODES DE PRONOSTIC ET DE TRAITEMENT DU CANCER COLORECTAL
Abstract:
(EN) A method for making a prognosis of colorectal cancer in a patient suffering from colorectal cancer is provided wherein the method comprises comparing PKC Beta II levels in a biological sample of colorectal cancer epithelial tissue and in a biological sample of normal distant epithelial tissue from the patient, wherein higher levels of PKC Beta II in the normal distant epithelial tissue sample than in the cancer sample indicate increased disease free survival. Also provided is a method for determining a suitable treatment for a patient suffering from colorectal cancer and a method for treating colorectal cancer comprising administering PKC Beta II or a drug which upregulates expression and/or activity of PKC Beta II to a subject in need thereof.
(FR) L'invention concerne une méthode permettant d'établir le pronostic du cancer colorectal chez un patient atteint d'un cancer colorectal, ladite méthode consistant à comparer les taux de PKC bêta II présents dans un échantillon biologique de tissu épithélial de cancer colorectal et dans un échantillon biologique de tissu épithélial normal distant prélevés chez le patient, la supériorité du taux de PKC bêta II présent dans le tissu épithélial normal distant par rapport au taux de PKC bêta II présent dans le tissu épithélial de cancer colorectal indiquant une survie sans progression plus longue. L'invention concerne également une méthode permettant de déterminer un traitement adapté pour un patient atteint d'un cancer colorectal et une méthode permettant de traiter le cancer colorectal consistant à administrer la PKC bêta II ou un médicament qui régule à la hausse l'expression et/ou l'activité de la PKC bêta II chez un sujet en ayant besoin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)