Search International and National Patent Collections

1. (WO2017153456) METHODS TO COMPRESS, ENCRYPT AND RETRIEVE GENOMIC ALIGNMENT DATA

Pub. No.:    WO/2017/153456    International Application No.:    PCT/EP2017/055414
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: G06F 19/22
G06F 19/28
Applicants: SOPHIA GENETICS S.A.
Inventors: MOLYNEAUX, Adam
AYDAY, Erman
HUBAUX, Jean-Pierre
GARCIA, Jesus
HUANG, Zhicong
LIN, Huang
Title: METHODS TO COMPRESS, ENCRYPT AND RETRIEVE GENOMIC ALIGNMENT DATA
Abstract:
A genomic data decoder may jointly compress and encrypt genomic data alignment information while preserving the privacy of sensitive genomic data elements at retrieval stage. Genomic data alignment information organized as a read-based alignment data stream may be transposed into a position-based alignment data stream. The position-based alignment information may been coded into a reference- based alignment data stream. The reference-based alignment data stream may be encrypted with a combination of order-preserving encryption of the genomic position information and symmetric encryption of the reference-based alignment differential data. Differential encoding and entropy coding schemes may further compress the reference-based alignment data stream. The resulting compressed and encrypted stream may be indexed and stored in a biobank storage unit. A genomic data decoder may efficiently retrieve, decrypt and decode a specific subset of the resulting compressed and encrypted stream without leaking information on the other genomic data subsets in the resulting stream.